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Related Experiment Videos

Viruses and apoptosis.

A Roulston1, R C Marcellus, P E Branton

  • 1GeminX Biotechnologies Inc., Montreal, Quebec, Canada. aroulston@geminx.com

Annual Review of Microbiology
|November 5, 1999
PubMed
Summary
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Viruses evade host defenses by manipulating apoptosis, or programmed cell death. Viral proteins block or delay apoptosis to ensure progeny production, offering potential therapeutic targets.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Viral replication necessitates progeny production and spread, alongside evading host defenses that eliminate infected cells.
  • Viral infections often trigger apoptosis (programmed cell death) in host cells, sometimes as a byproduct of viral functions or as a strategy for viral spread.
  • Viruses have evolved mechanisms to counteract host-induced apoptosis, crucial for successful replication.

Purpose of the Study:

  • To review current knowledge on the interplay between viruses and apoptosis.
  • To explore how viral manipulation of apoptosis impacts viral replication and pathogenesis.
  • To identify potential therapeutic strategies targeting viral apoptosis evasion mechanisms.

Main Methods:

  • Literature review of recent research on viruses and apoptosis.

Related Experiment Videos

  • Analysis of viral proteins that target apoptotic pathways.
  • Synthesis of information on the mechanisms of apoptosis evasion by viruses.

    • Main Results:

    • Most viruses induce apoptosis in infected cells, either as a necessary consequence of replication or as a means of spread.
    • Viruses encode proteins that specifically inhibit or delay apoptosis, protecting infected cells until viral progeny are produced.
    • Viral apoptosis inhibitors target key regulatory points within the host cell's apoptotic cascade.

    Conclusions:

    • Understanding how viruses manipulate apoptosis is critical for comprehending viral pathogenesis.
    • Viral strategies for controlling apoptosis present promising targets for the development of novel antiviral therapies.
    • Further research into virus-apoptosis interactions can illuminate new avenues for therapeutic intervention.