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Updated: Jul 14, 2026

Lipidomics and Transcriptomics in Neurological Diseases
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Published on: March 18, 2022

[Metabolism of enkephalins in various functional and pathological states of the body].

L F Panchenko1, N V Mitiushina, N V Firstova

  • 1Research Institute for Narcology Ministry of Public Health, Moscow.

Voprosy Meditsinskoi Khimii
|November 5, 1999
PubMed
Summary

The metabolism of enkephalins (neuropeptides) is influenced by organism conditions, pathology, and extreme factors. Enzyme systems regulating neuropeptide metabolism are crucial for their biological functions and roles in health and disease.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Physiology

Context:

  • Enkephalins are endogenous opioid neuropeptides involved in pain modulation, stress response, and other physiological processes.
  • Their metabolism is complex, involving synthesis and degradation by specific enzyme systems.
  • Understanding enkephalin metabolism is vital for comprehending their role in various physiological and pathological states.

Purpose:

  • To examine the metabolic peculiarities of enkephalins under diverse functional states, pathologies, and extreme environmental conditions.
  • To investigate the intricate relationship between enkephalins and the proteolytic enzymes responsible for their synthesis and degradation.
  • To elucidate how enzyme systems governing neuropeptide metabolism influence enkephalin function and biological activity.

Summary:

  • Enkephalin metabolism exhibits unique characteristics depending on the organism's functional status, presence of pathology, and exposure to extreme factors.
  • A significant focus is placed on the interplay between enkephalins and proteolytic enzymes involved in their metabolic pathways.
  • The study concludes that the functioning of enzyme systems is paramount to the biological properties and physiological/pathological roles of neuropeptides like enkephalins.

Impact:

  • This research highlights the critical role of enzyme systems in modulating enkephalin activity.
  • Findings provide insights into potential therapeutic targets for conditions involving altered enkephalin signaling.
  • The study underscores the importance of considering metabolic enzyme function when investigating neuropeptide involvement in health and disease.