Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug-food interactions].

D Cardona Pera1

  • 1Farmacia Hospital S. Creu i S. Pau, Barcelona, España.

Nutricion Hospitalaria
|November 5, 1999
PubMed
Summary
This summary is machine-generated.

Drug-food interactions can alter medication effectiveness and safety. Understanding these interactions, especially for narrow therapeutic index drugs, is crucial for patient health and preventing adverse events.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Oxidation of lipids contained in total parental nutrition].

Nutricion hospitalaria·2000
Same author

[Administration of glutamine and its dipeptides in parenteral nutrition. Which patients are candidates?].

Nutricion hospitalaria·1998
See all related articles

Area of Science:

  • Pharmacology
  • Drug Interactions
  • Food Science

Context:

  • Historically, significant drug-food interactions have been identified since the 1950s.
  • Interactions range from altered drug bioavailability to severe adverse events like hypertension and arrhythmias.
  • Modern research focuses on pharmacokinetic and pharmacodynamic alterations caused by food-drug interactions.

Purpose:

  • To review the historical and clinical significance of drug-food interactions.
  • To explore the pharmacokinetic (absorption, distribution, metabolism, excretion) and pharmacodynamic effects of food on drugs.
  • To provide guidance on how to take medications to avoid food-related interactions.

Summary:

  • Drug-food interactions occur when food alters a drug's clinical effect, impacting efficacy and safety.

Related Experiment Videos

  • Key historical examples include isoniazid with vitamin B6 deficiency and monoamine oxidase inhibitors with tyramine.
  • Grapefruit juice's inhibition of CYP3A4 leading to terfenadine toxicity highlights metabolic interactions.

    • Impact:

    • Highlights the importance of monitoring drug-food interactions, despite limited protocolization in healthcare settings.
    • Emphasizes the clinical relevance for drugs with a narrow therapeutic margin (e.g., digoxin, cyclosporine) and antibiotics requiring consistent plasma levels.
    • Informs patients on proper medication intake to mitigate risks associated with food-drug interactions.