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Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine
I C Weiss1, J Feldon, A M Domeney
1Behavioural Biology Laboratory, Swiss Federal Institute of Technology Zürich, Schwerzenbach.
Pharmacology, Biochemistry, and Behavior
|November 5, 1999
Summary
Circadian time did not affect acoustic startle response (ASR) or prepulse inhibition (PPI) in rats. Apomorphine
Area of Science:
- Neuroscience
- Chronobiology
- Behavioral Pharmacology
Background:
- Circadian rhythms influence physiological and behavioral processes.
- Prepulse inhibition (PPI) is a measure of sensorimotor gating.
- Apomorphine can modulate PPI, but its interaction with circadian time is unclear.
Purpose of the Study:
- To investigate the impact of circadian time on acoustic startle response (ASR) and prepulse inhibition (PPI).
- To examine whether circadian time influences apomorphine-induced deficits in PPI.
- To assess these measures in Wistar rats under a reversed light:dark cycle.
Main Methods:
- Wistar rats were housed under a reversed light:dark cycle.
- Experimental testing occurred during either the light or dark phase.
- Acoustic startle response (ASR), prepulse inhibition (PPI), and apomorphine-induced PPI deficits were measured.
Main Results:
- No significant differences were observed in ASR amplitude or PPI between light and dark phase testing.
- Apomorphine's effect on PPI was not modulated by circadian time.
- ASR, PPI, and apomorphine-induced PPI deficits were stable across the circadian cycle.
Conclusions:
- Circadian time does not significantly impact ASR, PPI, or apomorphine-induced PPI deficits in rats under the tested conditions.
- These findings support the stability of the PPI paradigm across the circadian cycle for research.
- Results are relevant for studies on brain plasticity and pharmacological manipulations in rats.