Related Experiment Video

Updated: Aug 18, 2026

Cardiac Magnetic Resonance Imaging at 7 Tesla
09:14

Cardiac Magnetic Resonance Imaging at 7 Tesla

Published on: January 6, 2019

Contrast agent-enhanced, free-breathing, three-dimensional coronary magnetic resonance angiography

M Stuber1, R M Botnar, P G Danias

  • 1Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. mstuber@caregroup.harvard.edu

Journal of Magnetic Resonance Imaging : JMRI
|November 5, 1999
PubMed

Insights

Intravascular contrast agents like MS-325/AngioMARK significantly improve coronary magnetic resonance angiography (MRA) image quality. This enhancement aids in visualizing coronary arteries with greater detail compared to traditional methods.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Medical Contrast Agents

Background:

  • High-resolution, three-dimensional coronary magnetic resonance angiography (MRA) requires effective contrast enhancement.
  • Distinguishing coronary blood from myocardium is crucial for accurate MRA interpretation.
  • Existing techniques like T2 prepulse (T2Prep) have limitations in achieving optimal contrast.

Purpose of the Study:

  • To evaluate the efficacy of the intravascular contrast agent MS-325/AngioMARK for coronary MRA.
  • To compare contrast enhancement and image quality with and without exogenous contrast agents.
  • To assess the potential of MS-325/AngioMARK in improving free-breathing, high-resolution coronary MRA.

Main Methods:

  • Six patients underwent free-breathing, three-dimensional inversion-recovery coronary MRA with real-time navigator gating.
  • Intravenous administration of 0.1 mmol/kg MS-325/AngioMARK.
  • Comparison of contrast-enhanced MRA images with T2Prep-only images.

Main Results:

  • MS-325/AngioMARK demonstrated a 69% improvement in contrast-to-noise ratio (11.1 +/- 2.5 vs. 6.6 +/- 1.1; P < 0.01).
  • Extensive portions (> 80 mm) of the coronary system were consistently displayed with sub-millimeter in-plane resolution.
  • Significant enhancement of blood/myocardium contrast was observed compared to T2Prep techniques.

Conclusions:

  • The intravascular contrast agent MS-325/AngioMARK significantly enhances coronary MRA image quality.
  • This agent enables detailed visualization of coronary arteries, surpassing T2Prep methods.
  • Further studies with larger patient cohorts are needed to define the clinical utility of MS-325/AngioMARK.

More Related Videos

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...