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Related Experiment Videos

An efficient MR phosphorous spectroscopic localization technique for studying ischemic heart.

H Liu1, J Zhang

  • 1Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA. haiying.liu-1@tc.umn.edu

Journal of Magnetic Resonance Imaging : JMRI
|November 5, 1999
PubMed
Summary

This study presents a novel nuclear magnetic resonance method for high-quality phosphorus-31 (31P) spectroscopic imaging of the myocardium. The technique achieves excellent spatial resolution and signal-to-noise ratio, crucial for studying cardiac ischemia.

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Area of Science:

  • Biophysics
  • Medical Imaging
  • Nuclear Magnetic Resonance Spectroscopy

Background:

  • Acute myocardial ischemia requires high signal-to-noise ratio (SNR) (31)P spectroscopic imaging within a limited time.
  • Existing methods face challenges in achieving both spatial resolution and speed for in vivo cardiac studies.

Purpose of the Study:

  • To develop and validate a rapid (31)P spectroscopic imaging technique for the in vivo myocardium.
  • To achieve high spatial resolution and SNR for studying acute myocardial ischemia.

Main Methods:

  • Exploited spatial variation of radiofrequency (RF) field from a single loop transmit/receive (TR) coil for spatial discrimination.
  • Encoded positional information using incrementally lengthened square RF excitation pulses.
  • Acquired 1D (31)P spectroscopic images using 17 encoding steps with cardiac and respiratory synchronization in an open-chest animal model.

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  • Total acquisition time was approximately 10 minutes.

    • Main Results:

    • Successfully obtained spatially resolved (31)P spectroscopic images from both phantom and in vivo myocardium.
    • Metabolite maps showed creatine phosphate and adenosine triphosphate peaks.
    • Detected 2,3-diphosphoglycerate peaks in the endocardium layer, indicating erythrocyte presence.
    • Method allowed compensation for volume and coil sensitivity variations.

    Conclusions:

    • The developed nuclear magnetic resonance method is efficient for high-quality (31)P spectroscopic imaging.
    • Achieves excellent spatial localization and SNR, suitable for cardiac ischemia research.
    • Demonstrates potential for non-invasive assessment of myocardial energetics and tissue composition.