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Measurement of post-lens tear thickness.

M C Lin1, A D Graham, K A Polse

  • 1Morton D. Sarver Laboratory for Cornea and Contact Lens Research School of Optometry, University of California at Berkeley, 94720-2020, USA. mlin@spectacle.berkeley.edu

Investigative Ophthalmology & Visual Science
|November 5, 1999
PubMed
Summary

Optical pachometry can measure post-lens tear thickness (PLTT) under soft contact lenses. This noninvasive technique offers precise measurements for contact lens research and group assessments.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Optometry

Background:

  • Accurate measurement of the tear film beneath soft contact lenses (post-lens tear thickness or PLTT) is crucial for advancing contact lens research.
  • Current methods may be invasive or lack precision, highlighting the need for novel, noninvasive techniques.

Purpose of the Study:

  • To present and validate a noninvasive optical pachometry technique for measuring post-lens tear thickness (PLTT).
  • To assess the feasibility and precision of optical pachometry for PLTT assessment in a human subject model.

Main Methods:

  • Optical pachometry was employed to measure corneal thickness before and after soft contact lens insertion.
  • Post-lens tear thickness (PLTT) was calculated using the formula: PLTT = T - (B + C), where T is total thickness, B is baseline corneal thickness, and C is contact lens center thickness.

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  • Measurements were repeated across two visits and at different time points post-lens insertion to ensure reliability.

    • Main Results:

    • Optical pachometry measurements of the tear layer in a model eye closely correlated with direct microscopic measurements.
    • Mean human PLTT values were consistently measured, with right eyes averaging 11-12 micrometers and left eyes 11-12 micrometers across visits.
    • The technique demonstrated good precision, with 95% confidence intervals indicating minimal variability in measurements.

    Conclusions:

    • Optical pachometry is a viable noninvasive method for measuring post-lens tear thickness (PLTT).
    • The demonstrated precision suggests this technique is suitable for group assessments in contact lens research, provided careful sample size planning.
    • This method holds potential for improving our understanding of soft contact lens performance and ocular surface interactions.