Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apo E influences declarative and procedural learning in age-associated memory impairment.

D Bartrés-Faz1, C Junqué, A López

  • 1Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Spain.

Neuroreport
|November 5, 1999
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications.

Blood·1998
Same author

Evaluation of the toxicity of guarana with in vitro bioassays.

Ecotoxicology and environmental safety·1998
Same author

Skin necrosis at the injection site induced by low-molecular-weight heparin: case report and review.

Dermatology (Basel, Switzerland)·1998
Same author

Severe hemolytic anemia due to multiple red cell alloantibodies after an ABO-incompatible allogeneic bone marrow transplant.

Transfusion·1998
Same author

Rectocele is associated with paradoxical anal sphincter reaction.

International journal of colorectal disease·1998
Same author

Prolonged pneumoperitoneum at 15 mmHg causes lactic acidosis.

Surgical endoscopy·1998

Individuals with the Apo E epsilon4 allele show reduced memory function in normal aging. This genetic factor may increase susceptibility to age-associated memory impairment.

Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Background:

  • Age-associated memory impairment (AAMI) affects memory in normal aging.
  • Apolipoprotein E (Apo E) and ACE genes are linked to cognitive decline and dementia.

Purpose of the Study:

  • To examine memory and executive functions in AAMI.
  • To investigate the influence of genetic background on cognitive performance in aging.

Main Methods:

  • Cognitive assessments were performed on subjects with AAMI.
  • Genetic analysis focused on Apolipoprotein E (Apo E) and ACE genes.

Main Results:

  • Subjects with the Apo E epsilon4 allele demonstrated poorer declarative and procedural memory performance.

Related Experiment Videos

  • No significant differences were observed in frontal lobe function tests.

    • Conclusions:

    • The Apo E epsilon4 allele is associated with diminished memory in aging.
    • Genetic factors, particularly Apo E, may predispose individuals to cognitive impairment during aging.