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Updated: Oct 18, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
Published on: September 17, 2019
Expression of gamma-glutamylcysteine synthetase mRNA in regenerating rat liver
1Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Abstract:
Changes in the level of GSH and gamma-Glutamylcysteine Synthetase (gamma-GCS) activity with time were determined during regeneration of rat liver after partial hepatectomy. The GSH level and gamma-GCS activity increased in regenerating rat liver, reaching a maximum (2.1- and 1.5-fold that in sham-operated controls) on day 2, respectively. Furthermore, gamma-GCS mRNA expression increased within 24 h and reached maximum on day 2. These results suggest that the increased GSH level in regenerating rat liver after partial hepatectomy is associated with the transcriptional activation of gamma-GCS gene and the sequence elevation in gamma-GCS activity.
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