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Renal microvasculature in acute renal failure
The Bulletin of Tokyo Medical and Dental University
|March 1, 1975
Summary
Acute renal failure involves reduced blood flow in the kidney
Area of Science:
- Nephrology
- Renal Physiology
- Vascular Biology
Background:
- Acute renal failure (ARF) has diverse causes and varied parenchymal damage.
- Understanding the renal microvasculature's response is crucial for ARF pathogenesis.
Purpose of the Study:
- To investigate the renal microvascular changes in acute renal failure.
- To explore the role of renin-angiotensin system in ARF.
Main Methods:
- Intraarterial silicone rubber injection in 10 human ARF cases.
- Experimental induction of ARF in dogs via renal artery ligation and angiotensin II infusion.
Main Results:
- Reduced cortical microvascular filling and preglomerular arteriole narrowing observed in human ARF.
- Similar patterns seen in experimentally induced canine ARF with angiotensin II.
- Increased filling in juxtamedullary cortex and vasa recta noted.
Conclusions:
- Preglomerular arteriole vasoconstriction is a common initial pathway in ARF.
- Renin and angiotensin likely play a role in acute renal failure pathogenesis.