Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaplastic large-cell lymphoma with rapid evolution to leukemic phase.

N Villamor1, M Rozman, J Esteve

  • 1Secció d'Hematopatologia, Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).

Annals of Hematology
|November 7, 1999
PubMed
Summary

Anaplastic large-cell lymphoma (ALCL), a rare T-cell malignancy, can present with a prominent leukemic phase. This case highlights a small-cell variant of ALCL with rapid leukemic progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Best practices to reduce microbial contamination during media-fill testing process in hospital pharmacies: a scoping review of literature.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025
Same author

Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target.

Nature communications·2025
Same author

Fungal Planet description sheets: 1781-1866.

Persoonia·2025
Same author

Perceived relevance of Planetary Health for Medical Students in Italy: Results from a mixed-methods analysis.

Public health in practice (Oxford, England)·2025
Same author

Blastic Plasmacytoid Dendritic Cell Neoplasm: A Single-Center Experience. Clinical Characterization, Mutational Landscape, and Clinical Outcome of Patients Undergoing Hematopoietic Stem Cell Transplantation Intensive Therapy.

Actas dermo-sifiliograficas·2024
Same author

Blastic Plasmacytoid Dendritic Cell Neoplasm: A Single-Center Experience. Clinical Characterization, Mutational Landscape, and Clinical Outcome of Patients Undergoing Hematopoietic Stem Cell Transplantation Intensive Therapy.

Actas dermo-sifiliograficas·2024

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Anaplastic large-cell lymphoma (ALCL) is a T-cell lymphoproliferative disorder.
  • Disseminated disease and extranodal involvement are common in ALCL.
  • A prominent leukemic phase in ALCL is exceptionally rare.

Observation:

  • This report details a patient with a small-cell variant of ALK-1 positive ALCL.
  • The patient developed a rapid leukemic phase coinciding with disease progression.
  • Peripheral blood and bone marrow showed predominant small atypical lymphoid cells.

Findings:

  • Large tumor cells exhibited cytoplasmic and nuclear ALK immunoreactivity.
  • Small atypical cells displayed nuclear-restricted ALK staining.
  • RT-PCR detected the NPM-ALK fusion gene in early disease but not post-chemotherapy.

Related Experiment Videos

Implications:

  • This case demonstrates that ALCL can manifest with a significant leukemic phase, often involving a small-cell component.
  • The NPM-ALK RT-PCR assay shows potential utility in monitoring treatment response in ALCL patients.
  • Understanding ALCL variants is crucial for accurate diagnosis and effective therapeutic strategies.