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Chemotherapy for intracranial ependymomas.

E Bouffet1, N Foreman

  • 1Children's Department, Royal Marsden Hospital NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK. ebouffet@icr.ac.uk

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|November 7, 1999
PubMed
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Chemotherapy shows limited effectiveness for pediatric intracranial ependymoma, with low response rates. Further rigorous studies are needed to define its role in treating this brain tumor.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Clinical Pharmacology

Background:

  • Intracranial ependymoma is a significant brain tumor in children.
  • Chemotherapy is a common treatment modality, but its efficacy is debated.

Purpose of the Study:

  • To review the effectiveness of chemotherapy in pediatric intracranial ependymoma.
  • To assess current evidence from phase II studies and clinical trials.

Main Methods:

  • Systematic review of phase II studies and clinical trials.
  • Analysis of response rates for single-agent and combination chemotherapy.

Main Results:

  • Single-agent chemotherapy yields an 11% response rate, with <5% complete responses.

Related Experiment Videos

  • Cisplatin shows the most activity among single agents.
  • High-dose combination regimens and early infant protocols show disappointing results.

    • Conclusions:

    • Current evidence suggests limited benefit of chemotherapy for pediatric intracranial ependymoma.
    • More large-scale, intergroup studies are essential to clarify chemotherapy's role.
    • Chemotherapy use outside of clinical trials is difficult to justify.