Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

D20S161 data for three ethnic populations and forensic validation.

Y P Hou1, Z M Jin, Y B Li

  • 1Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu 610041, Sichuan, P. R. China. rechtsme@wcums.edu.cn

International Journal of Legal Medicine
|November 7, 1999
PubMed
Summary

The short tandem repeat (STR) locus D20S161 is precise and reliable for forensic use. Its allele frequencies vary significantly across ethnic groups, making it valuable for casework and paternity testing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automatic segmentation of male pelvic floor soft tissue structures for anatomical simulation and morphological assessment in lower rectal cancer surgery.

Techniques in coloproctology·2025
Same author

Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review.

Musculoskeletal surgery·2024
Same author

Investigation of clinical utility of contrast-enhanced MRI in the diagnosis of ectopic pregnancy.

Clinical radiology·2020
Same author

Frequency and risk factors of thoracic metastases and optimisation of the use of cross-sectional chest imaging in follow-up patients with cervical cancer.

Clinical radiology·2019
Same author

European society of urogenital radiology (ESUR) guidelines: MR imaging of pelvic endometriosis.

European radiology·2016
Same author

Cell sheet injection as a technique of osteogenic supply.

International journal of stem cells·2014

Area of Science:

  • Forensic Genetics
  • Population Genetics

Background:

  • Short tandem repeat (STR) loci are crucial for forensic identification and paternity testing.
  • Evaluating new STR markers like D20S161 is essential for expanding forensic databases.

Purpose of the Study:

  • To assess the forensic applicability of the STR locus D20S161.
  • To establish a preliminary population database for D20S161.
  • To investigate genotype distributions and allele frequencies across diverse ethnic groups.

Main Methods:

  • Analysis of 512 unrelated individuals and 85 trios using PCR.
  • Allele determination via comparison with a sequenced human allelic ladder.
  • Population genetics analysis including Hardy-Weinberg equilibrium and pairwise comparisons.

Related Experiment Videos

Main Results:

  • D20S161 typing demonstrated high precision and reliability.
  • Seven alleles were identified across German, Slovakian, African American, Japanese, and Chinese populations.
  • Significant differences in allele frequencies were observed among the main ethnic groups.
  • No mutations were detected in trios, with an estimated mutation rate of 2.5 x 10(-5).

Conclusions:

  • D20S161 is a valuable genetic marker for forensic casework.
  • The locus shows utility in paternity analysis due to its discriminatory power.
  • Population-specific databases are important for accurate forensic interpretation.