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Circadian intraocular pressure variation with beta-blockers
S Krag1, H B Andersen, T Sørensen
1Department of Ophthalmology, Arhus University Hospital, Denmark.
Purpose:
To investigate circadian intraocular pressure variation in patients treated with topical beta-blockers as monotherapy.
Method:
Circadian IOP curves were measured on 25 patients (47 eyes) treated with topical beta-blockers. IOP was recorded 4 times during the day and twice at night. All IOP measurements were taken using a non-contact tonometer.
Results:
IOP at night was significantly higher than IOP during the day. Thirty-four percent exhibited an increase in IOP of more than 5 mmHg at night, and 15% exhibited an increase of 10-18 mmHg at night. The median range of circadian IOP variation was 7 mmHg. Determined separately by day, the range of IOP variation was 4 mmHg.
Conclusion:
Patients treated with beta-blockers as monotherapy may experience greater variations in IOP than can be detected by conventional daytime IOP measurements.