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Related Experiment Videos

Normal gallbladder ejection fraction after morphine augmentation.

D M Achong1, E Oates

  • 1Department of Radiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA. dwight.achong@es.nemc.org

Clinical Nuclear Medicine
|November 7, 1999
PubMed
Summary

Sincalide can induce normal gallbladder emptying after low-dose morphine sulfate administration. This finding supports using sincalide challenges to confirm gallbladder function in specific clinical scenarios.

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Area of Science:

  • Gastroenterology
  • Radiology
  • Pharmacology

Background:

  • Morphine sulfate is known to cause sphincter of Oddi spasm.
  • Sincalide, a cholecystagogue, promotes gallbladder contraction and sphincter of Oddi relaxation.

Purpose of the Study:

  • To assess if sincalide can normalize gallbladder emptying following low-dose morphine sulfate.
  • Evaluate the efficacy of sincalide in counteracting morphine-induced sphincter of Oddi dysfunction.

Main Methods:

  • Prospective study involving 24 patients.
  • Gallbladder ejection fractions measured 30-120 minutes post-morphine sulfate.
  • Sincalide (0.02 microg/kg) infused over 30 minutes.

Main Results:

Related Experiment Videos

  • 14 of 25 gallbladder ejection fractions were normal (mean 63%).
  • 11 of 25 gallbladder ejection fractions were abnormal (mean 12%).
  • Significant difference observed between normal and abnormal ejection fractions (P < 0.001).

    • Conclusions:

    • Normal gallbladder ejection fractions are achievable 30 minutes after low-dose morphine sulfate.
    • Sincalide challenge post-morphine may aid in diagnosing acute cholecystitis.
    • Supports the use of sincalide to confirm true-negative morphine-augmented gallbladder visualization.