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Increased I-131 uptake in local recurrence and distant metastases after second treatment with retinoic acid
C Koerber1, C Schmutzler, J Rendl
1Clinic of Nuclear Medicine, University of Würzburg, Germany.
Clinical Nuclear Medicine
|November 7, 1999
Abstract:
We present a case of increased I-131 uptake in a patient with papillary thyroid carcinoma with local recurrence and distant metastases after a second treatment with retinoic acid as a sign of redifferentiation of the tumor cells. When fine-needle aspiration cytology before and after a second course of retinoic acid treatment were compared, signs of tumor cell redifferentiation were found. This was accompanied by biochemical reexpression of thyroid marker proteins.