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Updated: Aug 12, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
Mytilus edulis histone gene clusters containing only H1 genes
1Institute of Biochemistry and Molecular Cell Biology, Department of Molecular Biology, Georg-August-University Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany. bdraben@gwdg.de
Abstract:
We isolated five different phage clones containing histone gene clusters with up to five H1 genes per phage clone from a Mytilus edulis genomic library. Among these H1 genes, nine gene types coding for five different H1 proteins have been identified. All H1 histone genes were located on repetitive restriction fragments with only slightly different sizes. The H1 coding regions show highly related sequences, suggesting that the multitude of H1 genes has evolved by gene duplication events. Core histone genes could not be found on these five Mytilus edulis genome fragments.
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