Related Experiment Video
Updated: Aug 16, 2026
08:30
Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
Published on: August 6, 2015
[Defects in autonomic regulation in myocardial ischemia]
Terapevticheskii Arkhiv
|December 20, 1999
Summary
Coronary heart disease patients with atherosclerosis and X syndrome patients exhibit distinct autonomic regulation maladaptation. This impacts cardiovascular function and myocardial ischemia development.
Area of Science:
- Cardiovascular Physiology
- Autonomic Nervous System Research
- Clinical Cardiology
Background:
- Autonomic dysregulation is implicated in cardiovascular disease.
- Understanding specific mechanisms in coronary heart disease (CHD) and X syndrome is crucial.
Purpose of the Study:
- To evaluate cerebral and peripheral autonomic regulation mechanisms.
- To assess their role in myocardial ischemia development in CHD patients with atherosclerosis and X syndrome.
Main Methods:
- Psychometric testing, cardiovascular tests, and spectral analysis of heart rate variability were employed.
- 36 patients (CHD with atherosclerosis, X syndrome) and 19 healthy controls participated.
Main Results:
- Both patient groups showed initial sympathicoadrenal activation with anxiety and depression.
- CHD patients had persistent sympathicoadrenal activation and baroreflex resistance.
- X syndrome patients displayed hemodynamic autonomic lability and baroreflex instability.
Conclusions:
- Coronary heart disease with atherosclerosis and X syndrome present different autonomic maladaptation mechanisms.
- These distinct patterns influence cardiovascular autonomic regulation and myocardial ischemia risk.
Related Concept Videos
01:28Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
01:29Pathophysiology of Cardiac Performance
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
01:31Regulation of Heart Rates
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
01:17Autoregulation of Blood Flow
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
01:21Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...