Related Experiment Video
Updated: Sep 28, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
[Response variability in pharmacotherapy]
Abstract:
The response obtained to drug administration can be modified by several factors which, from a synthetic point of view, can be classified into four basic groups: physical, chemical, biological and therapeutical. The first two can be verified and controlled by means of in-vitro test and, they must be known and solved before de final formulation is obtained. The other two factors, biological and therapeutical ones, introduce variables whose analysis concerns to the prescriptor. After this introduction, the variability in drug response is analyzed and discussed paying special attention to the pharmacokinetic and pharmacodynamic variability, analyzing the sources of such variability: environmental factors, factors depending of age, physical and genetical constitution, pathological states or drug interactions.
More Related Videos
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
09:12Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
Published on: March 17, 2019
Related Concept Videos
Factors Affecting Drug Response: Overview
Dosage Regimen: Individualization
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Pharmacodynamic Responses: Different Types
Drug Toxicity: Risk factors
Drug toxicity: Idiosyncratic Reactions