Related Experiment Videos
[Molecular biology studies of a multicenter phase III study (SIC Study)]
T Zimmermann1, S Albrecht, G von Gagern
1Klinik und Poliklinik für Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikums, TU Dresden. zialblcl@rcs.urz.tu-dresden.de
Medizinische Klinik (Munich, Germany : 1983)
|November 11, 1999
Summary
This study examines how transcription factors NF-kappa B and AP-1 influence inflammatory genes in sepsis patients. Findings aim to support sodium selenite therapy at a molecular level.
Area of Science:
- Molecular biology
- Immunology
- Critical care medicine
Background:
- Transcription factors regulate inflammatory gene expression.
- Sepsis involves complex inflammatory responses.
- The SIC-study (Selenium in Intensive Care) focuses on critical care patients.
Purpose of the Study:
- Investigate the role of NF-kappa B and AP-1 in Systemic Inflammatory Response Syndrome (SIRS)/septic patients.
- Corroborate the molecular mechanisms of sodium selenite therapy in sepsis.
- Understand the impact of transcription factors on inflammatory gene regulation in sepsis.
Main Methods:
- Analysis of transcription factor activity (NF-kappa B, AP-1) in sepsis.
- Molecular biological investigation within the SIC-study cohort.
- Assessment of gene expression related to inflammation.
Main Results:
- (Results not yet available in the abstract)
Conclusions:
- (Conclusions not yet available in the abstract)