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[Selenium administration in children with SIRS].

J Börner1, T Zimmermann, S Albrecht

  • 1Klinik und Poliklinik für Kinderchirurgie, Universitätsklinikum Carl Gustav Carus, TU Dresden. Jens.Boerner@mailbox.tu-dresden.de

Medizinische Klinik (Munich, Germany : 1983)
|November 11, 1999
PubMed
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Adjuvant selenium substitution in children with Systemic Inflammatory Response Syndrome (SIRS) improved selenium levels and antioxidant protection. This supportive therapy enhanced cell membrane protection and reduced lipid peroxidation in pediatric patients.

Area of Science:

  • Pediatric Surgery
  • Clinical Nutrition
  • Biochemistry

Background:

  • Severe inflammatory surgical diseases and extensive scalded skin in children can lead to Systemic Inflammatory Response Syndrome (SIRS).
  • Patients with SIRS often exhibit altered levels of essential nutrients and markers of oxidative stress.

Purpose of the Study:

  • To investigate the effects of adjuvant selenium substitution in pediatric patients diagnosed with SIRS.
  • To evaluate the impact of selenium on inflammatory markers, oxidative stress, and antioxidant enzyme activity.

Main Methods:

  • A cohort of pediatric patients (1-16 years) with SIRS was divided into a selenium substitution group (34 patients) and a control group (31 patients).
  • Laboratory parameters including white blood cell count, interleukin-6, C-reactive protein, fibrinogen, malondialdehyde, glutathione peroxidase activity, and selenium levels were measured.

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  • Measurements were taken on days 1, 2, 3, 6, and the last day of treatment.

    • Main Results:

    • Selenium substitution rapidly normalized plasma and blood selenium levels compared to the control group.
    • Glutathione peroxidase activity, an indicator of antioxidant protection, doubled in the selenium group, while remaining low in the control group.
    • Malondialdehyde levels, indicating lipid peroxidation, decreased to normal in the selenium group but remained elevated in the control group.

    Conclusions:

    • Adjuvant selenium substitution is a beneficial supportive therapy for pediatric patients with SIRS.
    • Selenium supplementation enhances antioxidant capacity and reduces oxidative stress in critically ill children.
    • This intervention may play a role in improving outcomes for children with severe inflammatory conditions.