Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homocysteine and atherosclerosis.

G T Gerhard1, P B Duell

  • 1Department of Medicine, Oregon Health Sciences University, Portland 97201-3098, USA. gerhardg@ohsu.edu

Current Opinion in Lipidology
|November 11, 1999
PubMed
Summary

Elevated total homocysteine is a significant risk factor for atherosclerotic vascular disease. Lowering homocysteine levels, primarily with folic acid, may reduce cardiovascular risk, though further trials are needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebrotendinous xanthomatosis without neurological involvement.

Journal of internal medicine·2021
Same author

Volanesorsen for treatment of patients with familial chylomicronemia syndrome.

Drugs of today (Barcelona, Spain : 1998)·2019
Same author

Clearance of plasma proprotein convertase subtilisin/kexin 9 by low-density lipoprotein apheresis.

Circulation research·2014
Same author

Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations.

Lipids·2002
Same author

Premenopausal black women are uniquely at risk for coronary heart disease compared to white women.

Preventive cardiology·2002
Same author

High plasma homocyst(e)ine levels in elderly Japanese patients are associated with increased cardiovascular disease risk independently from markers of coagulation activation and endothelial cell damage.

Atherosclerosis·2001

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Public Health

Background:

  • Elevated plasma total homocysteine is a recognized independent risk factor for atherosclerotic vascular disease.
  • Cardiovascular risk increases with rising homocysteine concentrations, becoming significant above 10 mumol/l.

Purpose of the Study:

  • To review the role of homocysteine in atherosclerotic vascular disease.
  • To discuss screening and treatment strategies for elevated homocysteine.
  • To highlight the need for further research on homocysteine-lowering therapies.

Main Methods:

  • Literature review of studies on homocysteine and cardiovascular disease.
  • Analysis of homocysteine levels and associated risks.
  • Evaluation of current and potential treatment options, including folic acid, vitamin B12, and vitamin B6.

Main Results:

  • Homocysteine levels greater than 10 mumol/l are associated with increased atherosclerotic risk.
  • Screening individuals with existing or high risk of atherosclerotic disease is recommended.
  • Folic acid is the primary treatment, with potential benefits from B12 and B6 in specific cases.

Conclusions:

  • Lowering plasma total homocysteine to below 10 mumol/l is a potential therapeutic goal.
  • Ongoing randomized trials are crucial to confirm whether homocysteine reduction translates to decreased cardiovascular disease risk.

Related Experiment Videos