Related Experiment Video
Updated: Oct 18, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
[Blood glucose and stroke]
M Nagi1, T Pfefferkorn, R L Haberl
1Abteilung für Neurologie und klinische Neurophysiologie, Städtisches Krankenhaus München-Harlaching.
Abstract:
There is strong evidence that severe hypoglycemia can worsen the prognosis in acute stroke. In contrast, the influence of acute hyperglycemia on cerebral ischemia remains controversial. The conflicting results of clinical and experimental studies can partly be explained if different stroke subtypes are regarded separately and the time course of the blood-glucose level during the acute insult is taken into account. Hyperglycemia seems to worsen the neuronal injury during the subacute period of cerebral ischemia if there is insufficient collateral blood supply. Furthermore, it increases the risk of hemorrhagic transformation in this time interval. In contrast, acute hyperglycemia may protect neuronal tissue from structural damage by improving the substrate supply if there is only a moderate decrease in cerebral blood flow. This situation is observed in the penumbra and if good collateral blood supply is provided. We therefore hypothesize that both negative and positive effects of acute hyperglycemia depend on the local cerebral blood flow.
Related Concept Videos
Hyperglycemia
Hypoglycemia
Stroke: Introduction and Types
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
