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Monocyte dysfunction in patients with multiple myeloma and lymphoplasmacytic disorders is related to serum

C J Mainwaring1, M A Williams, C R Singer

  • 1Department of Haematology, Royal United Hospital NHS Trust, Bath.

British Journal of Haematology
|November 11, 1999
PubMed

Insights

Monocyte function is impaired in multiple myeloma (MM) and Waldenström's macroglobulinaemia (WM), increasing infection risk. High paraprotein levels worsen this impairment, suggesting a target for future therapies.

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Monocyte dysfunction is implicated in lymphoplasmacytic disorders.
  • The impact of paraproteins on monocyte function requires further elucidation.

Purpose of the Study:

  • To investigate monocyte function in patients with lymphoplasmacytic disorders.
  • To determine the relationship between paraprotein levels and monocyte function.

Main Methods:

  • Assessed monocyte phagocytosis and candidacidal activity in patients and controls.
  • Correlated monocyte function with serum paraprotein levels.
  • Performed crossover studies to assess reversibility of abnormalities.

Main Results:

  • Marked monocyte function abnormalities observed in multiple myeloma (MM) and Waldenström's macroglobulinaemia (WM) patients.
  • Inverse relationship between paraprotein level and monocyte phagocytosis/killing capacity.
  • Abnormalities were largely constitutive but exacerbated by high paraprotein levels.

Conclusions:

  • Monocyte function is constitutively impaired in MM and further inhibited by paraproteins.
  • Potential for therapeutic interventions targeting monocyte function in MM and WM.
  • Further research needed to explore normalization with chemotherapy or growth factors.

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