Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain morphometric analysis in neurofibromatosis 1.

F J DiMario1, G R Ramsby, J A Burleson

  • 1Department of Pediatrics, University of Connecticut, University of Connecticut Health Center, Farmington, USA. fdimari@ccmckids.org

Archives of Neurology
|November 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of junk food marketing regulations on food sales: an ecological study.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
Same author

Clinical, Immune, and Microbiome Traits of Gingivitis and Peri-implant Mucositis.

Journal of dental research·2016
Same author

Effects of dehydroepiandrosterone (DHEA) on cardiovascular risk factors in older women with frailty characteristics.

Age and ageing·2010
Same author

Spouse caregivers of Alzheimer patients: problem responses to caregiver burden.

Aging & mental health·2006
Same author

Increased QT dispersion in breath-holding spells.

Acta paediatrica (Oslo, Norway : 1992)·2004
Same author

Vulnerability of husband and wife caregivers of Alzheimer disease patients to caregiving stressors.

Alzheimer disease and associated disorders·2001

Neurofibromatosis 1 (NF1) patients show distinct brain growth patterns, with larger supratentorial volumes and accelerated brainstem growth compared to controls. These findings highlight region-specific overgrowth in NF1.

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Genetics

Background:

  • Neurofibromatosis 1 (NF1) is a genetic disorder affecting nervous system development.
  • Brain and skull base morphometry in NF1 is not fully understood.

Purpose of the Study:

  • To compare brain and skull base growth in children with NF1 versus healthy controls.
  • To analyze morphometric differences using brain magnetic resonance imaging (MRI).

Main Methods:

  • Compared 27 children with NF1 to 43 age- and sex-matched controls using brain MRI.
  • Evaluated 24 brain and ventricular dimensions.
  • Utilized statistical analyses including t tests, chi-square, ANOVA, and ANCOVA.

Main Results:

Related Experiment Videos

  • Patients with NF1 showed significantly larger bicaudate width, biatrial width, and biparietal diameter.
  • Increased iter measures and descending sigmoid sinus width were observed in NF1.
  • NF1 patients exhibited an age-specific increase in brainstem height.

    • Conclusions:

    • NF1 is associated with lateral expansion of the supratentorial compartment.
    • Brainstem growth velocity increases with age in NF1 patients.
    • Data suggest brain-region-specific parenchymal overgrowth potential in NF1.