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Related Experiment Videos

Hepatitis C lookback programme: a single hospital experience.

R Pawson1, S Rajan, G Hazlehurst

  • 1Department of Hepatology, Royal Free Hospital, and North London Centre, National Blood Service, Colindale, London, UK.

Transfusion Medicine (Oxford, England)
|November 11, 1999
PubMed
Summary
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The Hepatitis C (HCV) Lookback Programme identified transfusion-transmitted HCV in recipients. Improved blood transfusion records are crucial for public health, especially for young patients.

Area of Science:

  • Transfusion Medicine
  • Hepatology
  • Infectious Diseases

Background:

  • The national Hepatitis C (HCV) Lookback Programme aimed to identify individuals who received blood from HCV-infected donors.
  • Blood donations after September 1991 from identified HCV-infected donors were traced to assess transfusion-transmitted infections.

Purpose of the Study:

  • To trace the fate of previous blood donations from identified HCV-infected donors.
  • To determine the prevalence of HCV infection among recipients of implicated blood components.
  • To evaluate the effectiveness of the HCV Lookback Programme in identifying transfusion-transmitted HCV.

Main Methods:

  • Identification of HCV-infected donors and tracing of their implicated blood donations.
  • Analysis of transfusion records to identify recipients of implicated blood components.

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  • Testing of surviving, traceable recipients for evidence of HCV infection.

    • Main Results:

    • 123 of 160 implicated blood components were traceable and transfused.
    • 19 recipients were alive and tested; 9 of 14 (64%) receiving HCV-positive donations and 2 of 5 (40%) receiving indeterminate donations were HCV-infected.
    • Neither donor exposure number nor component type predicted recipient HCV status; 3 recipients developed chronic active hepatitis.

    Conclusions:

    • The HCV Lookback Programme successfully identified some cases of transfusion-transmitted HCV.
    • Significant improvements are needed in transfusion record-keeping, especially in medical case notes.
    • Early identification of HCV in young recipients is critical due to the potential for chronic active hepatitis.