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Thalidomide in the treatment of refractory rheumatoid arthritis
N Keesal1, M J Wasserman, A Bookman
1Department of Medicine, University of Toronto, Centre for Advanced Therapeutics in Arthritis, Mount Sinai Hospital, Ontario, Canada.
The Journal of Rheumatology
|November 11, 1999
Abstract
Objective:
To review outcomes in 10 patients with rheumatoid arthritis (RA) treated with thalidomide.
Methods:
We reviewed our experience with 10 patients treated with thalidomide using a standard therapeutic protocol and standard outcome measures.
Results:
We observed no significant improvement in any outcome measure, likely as a consequence of the limited duration of therapy related to thalidomide toxicity.
Conclusion:
Formal studies of the efficacy of thalidomide in RA are required with alternative doses of the compound used by us, or with compounds derived from other sources.