Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vertebrate development: Multiple phases to endoderm formation.

L Dale1

  • 1Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. l.dale@ucl.ac.uk

Current Biology : CB
|November 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of steam cleaning technology on reducing the occurrence of ESKAPE organisms and Escherichia coli in the stables of an equine referral hospital.

Journal of equine veterinary science·2025
Same author

Rapid selection of milk mid-infrared spectra for creating a dairy cow population world representative spectral database.

Journal of dairy science·2024
Same author

Prediction of key milk biomarkers in dairy cows through milk mid-infrared spectra and international collaborations.

Journal of dairy science·2023
Same author

Recurrence of Breast Cancer After Primary Treatment: A Matched Comparison Study of Disease-Free Survival in Women Who Do and Do Not Receive Adjunctive Naturopathic Oncology Care.

Integrative cancer therapies·2021
Same author

Cumulative trauma disorders among hand therapists.

Work (Reading, Mass.)·2014
Same author

Stroke caregivers: do they feel prepared?

Occupational therapy in health care·2013
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Endoderm formation in amphibian embryos involves two steps. Initially, maternal factors like VegT specify endoderm, followed by maintenance through transforming growth factor-beta signaling.

Area of Science:

  • Developmental biology
  • Embryogenesis
  • Cell signaling

Background:

  • Endoderm formation is crucial for embryonic development.
  • Early amphibian endoderm specification involves localized maternal factors.
  • The role of extracellular signaling in endoderm maintenance requires further elucidation.

Purpose of the Study:

  • To investigate the two-step model of endoderm formation in amphibian embryos.
  • To identify the key molecular mechanisms underlying endoderm specification and maintenance.

Main Methods:

  • Analysis of maternal factors, including the transcription factor VegT.
  • Investigation of extracellular signaling molecules, specifically the transforming growth factor-beta (TGF-β) family.

Related Experiment Videos

Main Results:

  • Localized maternal factors, such as VegT, play a critical role in initial endoderm specification.
  • Extracellular signaling molecules of the TGF-β family are essential for maintaining endoderm fate.
  • Evidence supports a sequential two-step process for endoderm development.

Conclusions:

  • Amphibian endoderm formation is a two-step process involving initial specification and subsequent maintenance.
  • VegT is a key transcription factor for early endoderm specification.
  • TGF-β signaling is vital for the long-term maintenance of endoderm in developing embryos.