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Antigen presentation: TAP dances with ATP
J T Karttunen1, J Trowsdale, P J Lehner
1Department of Immunology, Wellcome Trust/MRC building, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XY, UK.
Current Biology : CB
|November 11, 1999
Abstract:
Assembly of antigen-presenting complexes between class I MHC molecules and peptide requires formation of a complex between the 'ABC' peptide transporter, TAP, and newly synthesized class I molecules. Recent studies have provided new insights into the role of ATP in peptide binding, transport and release.