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Related Experiment Videos

Can we predict which wheezy infants will continue to wheeze?

J B Clough1, K A Keeping, L C Edwards

  • 1Child Health, University of Southampton, Southampton General Hospital, Southampton, United Kingdom. jbc@soton.ac.uk

American Journal of Respiratory and Critical Care Medicine
|November 11, 1999
PubMed
Summary
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Predicting persistent infant wheeze is crucial for early intervention. Older children with atopy and both parents having atopy are more likely to have persistent wheeze, with age and soluble IL-2 receptor levels being key predictors.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Infant wheezing poses a challenge for early intervention due to difficulties in predicting disease persistence.
  • Identifying predictive factors for persistent wheeze is essential for developing targeted treatment strategies.

Purpose of the Study:

  • To prospectively identify factors that predict the persistence of wheeze in infants.
  • To develop a predictive model for persistent wheeze in young children.

Main Methods:

  • A prospective longitudinal study of 107 children (3-36 months) with at least one atopic parent, recruited within 12 weeks of their first wheeze.
  • Assessment of factors including personal and parental atopy, age at first wheeze, serum-soluble IL-2 receptor (sIL-2R), and immune cell responses.

Related Experiment Videos

  • Univariate and multivariate logistic regression analyses were used to identify predictor variables.

    • Main Results:

    • Persistent wheeze was observed in 49.5% of the children.
    • Older age at presentation, personal atopy, and biparental atopy were associated with a higher likelihood of persistent wheeze.
    • A predictive model combining age at presentation and serum-soluble IL-2 receptor levels offered the best prediction of persistent wheeze.

    Conclusions:

    • Early intervention strategies for infant wheezing can be enhanced by predicting disease persistence.
    • Age at presentation and serum-soluble IL-2 receptor levels are significant predictors of persistent wheeze.
    • The developed predictive model can aid in patient recruitment for early intervention trials.