Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Occupational exposure to genotoxic agents.

N Keshava1, T M Ong

  • 1Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, m/s 3014, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.

Mutation Research
|November 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of Bacillus cereus in foods by colony hybridization using PCR-generated probe and characterization of isolates for toxins by PCR.

International journal of food microbiology·2002
Same author

Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells.

Molecular and cellular biochemistry·2001
Same author

Distribution of HER2(V655) genotypes in breast cancer cases and controls in the United States.

Cancer letters·2001
Same author

Acceleration of mammary neoplasia in aromatase transgenic mice by 7,12-dimethylbenz[a]anthracene.

Cancer letters·2001
Same author

Tumorigenicity of morphologically distinct transformed foci induced by 3-methylcholanthrene in BALB/c-3T3 cells.

Mutation research·2001
Same author

Transforming and carcinogenic potential of cadmium chloride in BALB/c-3T3 cells.

Mutation research·2001

Millions of US workers face occupational exposure to genotoxic agents, potentially causing cancer and reproductive issues. This highlights the significant public health impact of workplace chemical exposures.

Area of Science:

  • Occupational Health
  • Toxicology
  • Genetics

Background:

  • Millions of US workers are exposed to hazardous occupational agents like chemicals, dusts, and fibers annually.
  • Some agents are genotoxic, capable of causing genetic alterations in somatic or germ cells.
  • These alterations can impact proto-oncogenes and tumor suppressor genes, potentially leading to cancer.

Purpose of the Study:

  • To highlight the risks of occupational exposure to genotoxic agents.
  • To emphasize the link between occupational exposures and cancer development.
  • To underscore the potential for reproductive health impacts from workplace hazards.

Main Methods:

  • This abstract summarizes existing knowledge on occupational exposures and their health effects.

Related Experiment Videos

  • It reviews the mechanisms by which genotoxic agents can lead to cancer.
  • It cites estimates on the prevalence and mortality associated with occupational cancer.

    • Main Results:

    • Occupational exposure is linked to significant cancer risks, accounting for 4% of all human cancers.
    • An estimated 20,000 cancer deaths annually in the US are attributable to occupational exposure.
    • Genotoxic alterations in germ cells may result in reproductive failure or genetic disorders.

    Conclusions:

    • Occupational cancer and reproductive abnormalities are significant public health concerns.
    • These conditions are recognized as major occupational diseases on research agendas.
    • Further research and preventative measures are crucial to mitigate these risks.