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Related Experiment Videos

Hyperalgesic response to noxious stimulation in genetically polydipsic mice.

H Kamikawa1, T Katafuchi, M Hosoi

  • 1Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Brain Research
|November 11, 1999
PubMed
Summary

STR/N mice exhibit hyperalgesia, showing reduced pain sensitivity to opioid agonists. This suggests a down-regulated opioid system, similar to chronic morphine users, which can be reversed with naltrexone treatment.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • STR/N mice display extreme polydipsia and polyuria without abnormal vasopressin response.
  • Previous research implicated the brain opioid system in STR/N mice's polydipsia.

Purpose of the Study:

  • Investigate the nociceptive threshold and opioid receptor sensitivity in STR/N mice.
  • Determine if the opioid system's anti-nociceptive function is impaired in STR/N mice.

Main Methods:

  • Assessed paw-withdrawal latency (PWL) on a hot-plate in STR/N mice and controls (BALB/c, C3H).
  • Administered morphine and a kappa-opioid receptor agonist (U50,488H) to evaluate anti-nociceptive effects.
  • Utilized repeated naltrexone administration to attempt up-regulation of the opioid system.

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Main Results:

  • STR/N mice exhibited significantly shorter PWL compared to controls, indicating hyperalgesia.
  • Morphine and U50,488H failed to prolong PWL in STR/N mice, unlike in control groups.
  • Repeated naltrexone treatment restored morphine's anti-nociceptive effect in STR/N mice.

Conclusions:

  • STR/N mice possess a down-regulated anti-nociceptive opioid system.
  • This impairment resembles that seen in animals with chronic morphine exposure.
  • Opioid system up-regulation can restore analgesia in STR/N mice.