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An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase
1Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, QC, H3C 3J7 (Canada).
Angewandte Chemie (International Ed. in English)
|November 11, 1999
Abstract:
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.