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Malignant fibrous histiocytoma after allogeneic bone marrow transplantation
J Vela-Ojeda1, L Diaz de León, F Tripp-Villanueva
1Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico DF, Mexico.
Bone Marrow Transplantation
|November 11, 1999
Abstract:
A 24-year-old woman with CML underwent allogeneic BMT in August 1995 from a one-antigen HLA mismatched brother. Conditioning included BuCy2 and CsA and MTX were used to prevent GVHD. In July 1997 she developed right leg pain, lytic bone lesions of distal femur and a solid mass of soft tissue. Histological diagnosis of malignant fibrous histiocytoma was made. Despite treatment with surgery and chemotherapy (doxorubicin and ifosfamide), the patient died 1 year later with local recurrence of the tumor and liver, lung and brain metastases. The CML was in CR.