Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide and Drosophila development.

G Enikolopov1, J Banerji, B Kuzin

  • 1Cold Spring Harbor Laboratory Cold Spring Harbor, NY 11724, USA. enik@cshl.org

Cell Death and Differentiation
|November 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive case management of malaria: Operational research informing policy.

Journal of vector borne diseases·2019
Same author

Hollow Gaussian beam generation through nonlinear interaction of photons with orbital angular momentum.

Scientific reports·2016
Same author

Brain stem cell division and maintenance studied using multi-isotope imaging mass spectrometry (MIMS).

Surface and interface analysis : SIA·2015
Same author

Divergence of optical vortex beams.

Applied optics·2015
Same author

Higher order optical vortices and formation of speckles.

Optics letters·2014
Same author

Propagation of an arbitrary vortex pair through an astigmatic optical system and determination of its topological charge.

Journal of the Optical Society of America. A, Optics, image science, and vision·2014
Same journal

A planar dimer of bovine ATP synthase.

Cell death and differentiation·2026
Same journal

GCN5 and TADA2B constitutively regulate XRCC1 function during DNA repair to maintain cell survival.

Cell death and differentiation·2026
Same journal

MEGF8 controls osteogenic differentiation through post-transcriptional regulation of BMP-SMAD signaling in craniosynostosis.

Cell death and differentiation·2026
Same journal

Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis.

Cell death and differentiation·2026
Same journal

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026
Same journal

Ssu72 phosphatase orchestrates obesogenic adipogenesis and metabolic homeostasis during nutrient excess.

Cell death and differentiation·2026
See all related articles

Nitric oxide (NO) regulates cell proliferation and differentiation during development. This study shows NO acts as a negative regulator, controlling tissue and organ formation in developing organisms.

Area of Science:

  • Developmental biology
  • Cell signaling
  • Molecular biology

Background:

  • Cell proliferation and differentiation are critical for organism development.
  • Nitric oxide (NO) is a signaling molecule with known roles in various physiological processes.
  • The precise role of NO in developmental transitions remains to be fully elucidated.

Purpose of the Study:

  • To investigate the role of nitric oxide (NO) in regulating precursor cell proliferation and differentiation.
  • To determine if NO acts as a negative regulator during tissue and organ morphogenesis.

Main Methods:

  • Utilizing Drosophila melanogaster as a model organism.
  • Manipulating nitric oxide synthase (NOS) activity in imaginal discs.
  • Analyzing the effects of NOS inhibition and overexpression on tissue and organ size.

Related Experiment Videos

  • Examining the impact of NO on neuronal development in the visual system.

    • Main Results:

    • Inhibition of NOS activity led to tissue and organ hypertrophy in adult flies.
    • Ectopic overexpression of NOS resulted in hypotrophy.
    • NO production was essential for the formation of organized neuronal connections.
    • NO influences the acquisition of differentiated phenotypes in neural tissues.

    Conclusions:

    • Nitric oxide (NO) plays a crucial role in regulating precursor cell proliferation during development.
    • NO acts as a negative regulator, controlling tissue and organ morphogenesis.
    • NO is essential for proper neuronal development and differentiation.