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Lack of association between a human beta-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity
1Klinik für Allgemeinchirurgie, Evangelisches und Johanniter Klinikum, Dinslaken, Germany.
Objective:
To determine the frequency of the gln27glu polymorphism in the beta-2 adrenoceptor gene in patients with morbid obesity.
Subjects:
243 patients with morbid obesity (mean body mass index 51. 6) and 199 healthy blood donors.
Results:
The same frequency, 0.42, of the glu allele was observed in both groups. Neither the incidence in obese women (0.41, n=197) compared to control women (0.43, n=61), nor that in obese men (0.44, n=46) compared to control men (0.41, n=138) was significantly different. The difference in frequency between obese men and women, 0.44 vs 0.41 was not significant (P=0. 68). Genotype information from the families of 18 of the obese patients showed no association between the glu27 allele and BMI.
Conclusions:
We find no evidence for a role of the glu27 variant in the beta-2 adrenoceptor gene in the development of morbid obesity.