Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and coagulation: causative considerations in contrast catastrophies.

E C Lasser, J Slivka, J H Lang

    AJR. American Journal of Roentgenology
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Chinese Expert Consensus on GnRH-a in Obstetrics and Gynecology].

    Zhonghua fu chan ke za zhi·2025
    Same author

    [Analysis of risk factors and predictive model construction for Roux-en-Y stasis syndrome after distal gastrectomy for gastric cancer].

    Zhonghua yi xue za zhi·2025
    Same author

    [Do not injury, please！].

    Zhonghua fu chan ke za zhi·2025
    Same author

    [Coexistence of development and expectation, balancing tasks and responsibilities].

    Zhonghua fu chan ke za zhi·2025
    Same author

    [Attention doctor colleagues, please do not discard your tethoscope!]

    Zhonghua fu chan ke za zhi·2024
    Same author

    [The value and significance of classification, staging and grading in the diagnosis and therapy of diseases].

    Zhonghua fu chan ke za zhi·2024
    Same journal

    The Banality of Cancer: Entropy As a Third Pillar of Lung Nodule Risk Assessment.

    AJR. American journal of roentgenology·2026
    Same journal

    A Narrow Window for Artificial Intelligence-Generated Synthetic Temporal Bone CT From MRI.

    AJR. American journal of roentgenology·2026
    Same journal

    From Uncertainty to Actionable Management: The Isolated Abnormal Axillary Lymph Node.

    AJR. American journal of roentgenology·2026
    Same journal

    Beyond Detection: Translating Artificial Intelligence-Driven Opportunistic Screening Into Clinical Action.

    AJR. American journal of roentgenology·2026
    Same journal

    Navigating PSMA PET Radiopharmaceuticals: Clinical and Operational Factors.

    AJR. American journal of roentgenology·2026
    Same journal

    From Mesenteric Ischemia to Intestinal Stroke.

    AJR. American journal of roentgenology·2026
    See all related articles

    Adverse reactions to radiographic contrast media are linked to coagulation system activation. Depleting fibrinogen significantly reduced mortality in rabbit models, suggesting a primary role for coagulation in these events.

    Area of Science:

    • Medical Imaging
    • Pharmacology
    • Immunology

    Background:

    • Adverse reactions to radiographic contrast media are often considered idiosyncratic.
    • Understanding the pathophysiologic mechanisms underlying these reactions is crucial for patient safety.

    Purpose of the Study:

    • To investigate the roles of complement and coagulation systems in contrast media-induced adverse reactions.
    • To elucidate the specific components involved in contrast media-related mortality in a rabbit model.

    Main Methods:

    • Rabbits were injected with lethal doses of cholangiographic contrast material.
    • Complement and coagulation systems were monitored for activation.
    • Complement components (C3-C9) were depleted using cobra venom factor.
    • Fibrinogen was depleted, and heparin was administered to assess their impact on mortality and system activation.

    Related Experiment Videos

    Main Results:

    • Contrast media injection activated both complement and coagulation systems.
    • Externally applied heat potentiated complement consumption and increased mortality.
    • Depletion of complement components C3-C9 did not prevent coagulation activation or reduce mortality.
    • Fibrinogen depletion significantly reduced complement activation and mortality.
    • Heparin administration also diminished mortality.

    Conclusions:

    • Adverse effects of contrast media in this model are primarily mediated by the coagulation system.
    • Complement system involvement appears to be upstream of C3.
    • The inhibitor of C1 esterase may play a role in mitigating adverse contrast reactions.