Related Experiment Video
Updated: Jul 11, 2026

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
Published on: June 21, 2015
The O'Flaherty model of lead kinetics: an evaluation using data from a lead smelter population
D E Fleming1, D R Chettle, C E Webber
1Department of Biomedical Technologies, University of Vermont, Burlington, Vermont, 05405-0068, USA.
Abstract:
The O'Flaherty model of lead kinetics is a physiologically based computer model of lead disposition in humans. The model is based on an age-dependent approach to human growth, with particular attention devoted to bone metabolism. As such, model output is well suited for comparison with noninvasive bone lead measurements made via X-ray fluorescence. A subset of workers from a lead smelter population were selected for an initial evaluation of the O'Flaherty model. Detailed blood lead records were used to define input. Simulated bone lead and blood lead output were compared with observation, enabling a refinement of model parameters. A revised version of the O'Flaherty model was then evaluated for the smelter population as a whole. Previously observed trends for the accumulation of lead in cortical bone and the release of lead from bone stores were well explained by the revised model. Model predictions for the accumulation of lead in trabecular bone were not in accord with observed levels in the calcaneus. Model results from the smelter population are consistent with the hypothesis that a polymorphism in the delta-aminolevulinate dehydratase enzyme modifies the kinetics of lead in humans. Further refinements are suggested, which may enhance the ability of the model to explain the underlying relationships between lead exposure and the distribution of lead in the body.
Related Concept Videos
The Integrated Rate Law: The Dependence of Concentration on Time
Extraction: Advanced Methods
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Pharmacodynamic Models: Linear Concentration–Effect Model
Microbial Leaching

