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Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus
A S Pereira1, A D Kashuba, S A Fiscus
1Department of Pathology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
The Journal of Infectious Diseases
|November 24, 1999
Abstract:
Human immunodeficiency virus (HIV) can be transmitted in semen from a man to his sexual partners. Antiretroviral drugs are likely to affect the amount of HIV-1 in semen and perhaps transmission of the virus. The concentrations of zidovudine, lamivudine, and HIV-1 RNA in blood and seminal plasma were measured in 9 HIV-positive men over