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Related Experiment Video

Updated: Apr 3, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Measles elimination: progress and challenges.

F T Cutts1, A Henao-Restrepo, J M Olivé

  • 1Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK. f.cutts@lshtm.ac.uk

Vaccine
|November 24, 1999
PubMed
Summary
This summary is machine-generated.

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Global measles eradication is achievable within 10-15 years, but requires addressing political, financial, and technical challenges, especially in Africa. Improving vaccination coverage and surveillance is key to eliminating this infectious disease.

Area of Science:

  • Public Health
  • Infectious Disease Epidemiology
  • Vaccinology

Background:

  • Measles incidence and mortality have significantly decreased globally, prompting calls for eradication.
  • The Americas region has successfully reduced measles transmission through a multi-pronged strategy.
  • Significant challenges remain, particularly in western and central Africa, where vaccination rates are low and measles mortality is high.

Purpose of the Study:

  • To assess the feasibility and challenges of global measles eradication.
  • To review successful measles elimination strategies and identify areas for improvement.
  • To highlight the critical need for enhanced measles control in low-income countries.

Main Methods:

  • Review of regional measles elimination strategies, focusing on the Americas model.

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  • Analysis of current measles control status, vaccination coverage, and mortality rates globally.
  • Identification of political, financial, and technical obstacles to eradication.

    • Main Results:

    • The Americas' strategy, combining mass vaccination, routine immunization, and surveillance, has drastically reduced measles transmission.
    • Less than 50% of children in western and central Africa receive the measles vaccine, contributing to high mortality.
    • Political and financial hurdles are primary obstacles, alongside technical questions regarding HIV, injection safety, and vaccine efficacy.

    Conclusions:

    • Global measles eradication is a realistic goal but necessitates sustained political will and financial investment.
    • Targeted interventions are crucial to improve measles control in under-vaccinated regions.
    • Further research is needed to address technical aspects of measles elimination strategies.