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Updated: Aug 10, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
Tubular epithelial cells: A critical cell type in the regulation of renal inflammatory processes
C van Kooten1, M R Daha, L A van Es
1Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Kooten@rullf2.Medfac.LeidenUniv.nl
Abstract:
Most chronic human kidney diseases are characterized by a final common pathway consisting of interstitial inflammation and ultimately leading to interstitial fibrosis. Within this process, tubular epithelial cells (TECs) play a critical role. Both in vitro and in vivo it has been demonstrated that TECs are an important source of various cytokines, chemokines, growth factors, adhesion molecules and extracellular matrix components. In the present review we will outline the capacity of TECs to produce inflammatory mediators and discuss the different mechanisms involved in the regulation of production of these mediators.
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