Related Experiment Video
Updated: Aug 10, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
One-year outcome in multivessel coronary disease patients undergoing coronary stenting
S De Servi1, G Mariani, I Bossi
1Division of Cardiology and Direzione Scientifica, Policlinico S. Matteo, Pavia, Italy.
Insights
Coronary stenting in multivessel coronary artery disease (CAD) showed favorable 1-year clinical outcomes. Repeat revascularization rates were lower than with conventional angioplasty, indicating improved patient results after stent implantation.
Area of Science:
- Interventional Cardiology
- Cardiovascular Disease Research
- Medical Device Technology
Background:
- Multivessel coronary artery disease (CAD) presents complex treatment challenges.
- Coronary stenting has emerged as a key intervention for managing CAD.
- Assessing long-term clinical outcomes post-stenting is crucial for patient management.
Purpose of the Study:
- To evaluate the 1-year clinical outcomes of patients with multivessel CAD undergoing coronary stenting.
- To compare the efficacy of coronary stenting versus conventional percutaneous transluminal coronary angioplasty (PTCA) in terms of major adverse cardiac events and repeat revascularization.
Main Methods:
- Prospective enrollment of 377 patients with multivessel CAD in the Registro Impianto Stent Endocoronarico (RISE) registry.
- All patients underwent percutaneous transluminal coronary angioplasty (PTCA) with single or multiple stent implantation.
- Major adverse cardiac events (death, myocardial infarction, target vessel revascularization) were tracked for 1 year.
Main Results:
- Angiographic success rate was high at 98.5%.
- The cumulative incidence of death, myocardial infarction, and repeat revascularization at 1 year was 2.9%, 4.7%, and 10.8%, respectively.
- Factors associated with 1-year major cardiac events included multiple stent implantation, left anterior descending artery revascularization, and stent length.
Conclusions:
- Coronary stenting in patients with multivessel CAD demonstrates favorable 1-year clinical outcomes.
- The need for repeat revascularization procedures following stenting is lower compared to conventional PTCA.
- Ticlopidine therapy and high-pressure balloon dilation were associated with reduced major cardiac events.
Abstract:
The purpose of this study was to assess 1-year clinical outcome of patients with multivessel coronary artery disease (CAD) who underwent coronary stenting and were prospectively enrolled in the Registro Impianto Stent Endocoronarico (RISE). Of 939 consecutive patients included in the registry, 377 patients with angiographic evidence of multivessel CAD had a 1-year clinical follow-up. All patients underwent PTCA and single or multiple stenting in at least one vessel. Angiographic optimization was usually performed by using high-pressure balloon dilation. After the procedure, continuation of aspirin (at least 250 mg/day) was recommended, whereas the use of anticoagulation or ticlopidine was determined by the physician in charge of the patient in the various centers. Major adverse cardiac events were defined as death, Q-wave or non-Q-wave myocardial infarction and target vessel revascularization. Mean age of patients (311 men, 66 women) was 60 +/- 10 years. Globally, there were 596 stents implanted (72% Palmaz-Schatz stents) in 434 vessels. In about 75% of the procedures, an inflation pressure > 12 atm was used. Angiographic success rate was 98.5%. After stenting, 77% of patients received antiplatelet treatment with ticlopidine and aspirin. During hospitalization, there were 34 major adverse cardiac events in 24 patients. At 1-year follow-up, 309 patients were alive and event-free; cumulative incidence of death, myocardial infarction, and repeat revascularization were 2.9%, 4.7%, and 10.8%, respectively. By Cox regression analysis, multiple stents implantation (HR 1.72, 95% CI 1-2.97), left anterior descending artery revascularization (HR 1.86, 95% CI 1.01-3.42), use of inflation pressure > 12 atm (HR 0.93, 95% CI 0.89-0.97), ticlopidine therapy (HR 0.41, 95% CI 0.23-0.74), and stent length (HR 1.03, 95% CI 1.01-1.05) were associated with 1-year major cardiac events. In patients with multivessel CAD undergoing stent implantation in at least one vessel, 1-year follow-up is favorable and the need for repeat revascularization procedures, based on clinical data, is lower than previously reported for conventional PTCA. Cathet. Cardiovasc. Intervent. 48:343-349, 1999.
