Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A deterministic approach to automated stenosis quantification.

G Tommasini1, P Rubartelli, M Piaggio

  • 1Divisione di Cardiologia, E.O. Ospedali Galliera, Genova, Italy. giortomm@iol.it

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|November 24, 1999
PubMed
Summary

A new quantitative coronary angiography (QCA) approach offers improved reproducibility and accuracy. This operator-independent method enhances stenosis identification and measurement in coronary angiography, advancing cardiac imaging analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiation doses in cerebral perfusion computed tomography: patient and phantom study.

Radiation protection dosimetry·2012
Same author

Intra-arterial Chemotherapy with Carboplatin (CBDCA) and Vepesid (VP16) in Primary Malignant Brain Tumours. Preliminary Findings.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same author

Alcohol septal ablation in the management of obstructive hypertrophic cardiomyopathy.

Italian heart journal : official journal of the Italian Federation of Cardiology·2000
Same author

One-year outcome in multivessel coronary disease patients undergoing coronary stenting.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·1999
Same author

[Assessment of early or delayed invasive treatment of patients with unstable angina/non-Q infarction. Study Group AVOID-PTCA].

Giornale italiano di cardiologia·1999
Same author

[Nephrotic syndrome refractory to conventional therapy].

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·1999

Area of Science:

  • Cardiovascular Imaging
  • Medical Image Analysis
  • Interventional Cardiology

Background:

  • Conventional quantitative coronary angiography (QCA) programs suffer from operator dependence, limited tracking, fixed point spread function (PSF) correction, and inconsistent catheter calibration.
  • These limitations impact the reproducibility and accuracy of coronary artery stenosis assessment.

Purpose of the Study:

  • To introduce and evaluate a novel, operator-independent QCA approach designed to overcome existing limitations.
  • To enhance the accuracy, precision, and reproducibility of coronary artery stenosis quantification.

Main Methods:

  • Development of the Intelligent Images QCA program (version 1.4) featuring deterministic identification of coronary tree structures.
  • Algorithm includes matched filtering, adaptive binarization, skeletonization, resampling, derivative filtering, and minimal cost edge detection.

Related Experiment Videos

  • Operator interaction is limited to region definition; PSF and catheter calibration are automated and refined using phantoms and edge detection.

    • Main Results:

    • In vitro phantom studies demonstrated high accuracy (0.028-0.031 mm) and precision (0.054-0.062 mm).
    • In vivo evaluation showed 96% correct stenosis contour detection, 0.00 mm interobserver variability in minimum lumen diameter (MLD), and 100% correct catheter edge tracking.
    • Catheter calibration showed a 3.3% interobserver variation coefficient and a 2.7% mean difference between contrast-filled and empty catheters.

    Conclusions:

    • The new QCA approach significantly improves reproducibility compared to conventional methods.
    • It maintains high levels of accuracy, precision, and applicability for coronary angiography analysis.
    • This automated system offers a more reliable tool for assessing coronary artery disease.