Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transport-vesicle targeting: tethers before SNAREs.

S R Pfeffer1

  • 1Department of Biochemistry, Stanford University School of Medicine, California 94305-5307, USA.

Nature Cell Biology
|November 13, 1999
PubMed
Summary

Vesicle targeting ensures correct protein delivery within cells. Emerging protein families and common themes explain how these vesicles find their destinations for timely cargo release in eukaryotic cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

British journal of cancer·2011
Same author

Constructing a Golgi complex.

The Journal of cell biology·2001
Same author

Rab GTPases: specifying and deciphering organelle identity and function.

Trends in cell biology·2001
Same author

Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.

Science (New York, N.Y.)·2001
Same author

Caveolae on the move.

Nature cell biology·2001
Same author

TIP47 is not a component of lipid droplets.

The Journal of biological chemistry·2001

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein secretion and intracellular transport rely on membrane-bound vesicles.
  • Vesicle targeting is crucial for delivering proteins to specific cellular locations.

Purpose of the Study:

  • To review the current understanding of vesicle targeting mechanisms.
  • To explore the roles of emerging protein families in vesicle transport.
  • To identify common principles governing vesicle destination recognition.

Main Methods:

  • Literature review of vesicle targeting research.
  • Analysis of protein families involved in vesicle trafficking.
  • Synthesis of emerging themes in cellular transport.

Main Results:

  • Vesicle targeting involves a diverse and growing set of proteins.
  • Common mechanisms are being identified across different vesicle types.
  • Understanding how vesicles identify targets and release cargo is advancing.

Conclusions:

  • Vesicle targeting is a complex process mediated by numerous proteins.
  • Emerging common themes provide insights into the specificity and regulation of vesicle transport.
  • Further research is needed to fully elucidate the modes of action for these targeting proteins.

Related Experiment Videos