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Regulation of the APC and the exit from mitosis

D O Morgan1

  • 1Department of Physiology, University of California, San Francisco 94143-0444, USA. dmorgan@cgl.ucsf.edu

Nature Cell Biology
|November 13, 1999
PubMed

Insights

The anaphase-promoting complex (APC) controls key events in late mitosis, including sister-chromatid separation and cytokinesis, by degrading regulatory proteins. Its intricate regulation ensures precise timing and coordination of these crucial cell division processes.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Late mitotic events, including sister-chromatid separation and cytokinesis, are critical for cell division.
  • The anaphase-promoting complex (APC) is a key regulator of these late mitotic processes.
  • APC activity is tightly controlled by an intricate regulatory network.

Purpose of the Study:

  • To elucidate the regulatory mechanisms governing the anaphase-promoting complex (APC).
  • To understand how APC activity ensures the proper timing and coordination of late mitotic events.

Main Methods:

  • The study likely involved biochemical assays to analyze APC composition and activity.
  • Genetic approaches may have been used to identify regulatory components.
  • Proteomic techniques could have been employed to study protein degradation pathways.

Main Results:

  • The anaphase-promoting complex (APC) governs crucial late mitotic events.
  • APC triggers ubiquitin-dependent proteolysis of key regulatory proteins.
  • An intricate regulatory network precisely controls APC activity.

Conclusions:

  • The coordinated regulation of the anaphase-promoting complex (APC) is essential for accurate cell division.
  • Understanding APC regulation provides insights into cell cycle control and potential therapeutic targets.

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