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Updated: Aug 15, 2026

Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
Lipoprotein receptors: new roles for ancient proteins
T E Willnow1, A Nykjaer, J Herz
1Max-Delbrück-Center for Molecular Medicine, R. Rössle Strasse 10, 13125 Berlin, Germany.
Abstract:
Lipoprotein receptors used to be viewed simply as the means by which cells were supplied with lipids for energy production and membrane synthesis. This perception has now changed dramatically. Megalin, a member of the low density lipoprotein receptor gene family, turns out to mediate the endocytic uptake of retinoids and steroids, thus helping to regulate their biological function. Other members of this receptor family interact with cytosolic signalling proteins, giving this evolutionarily ancient family of receptors an entirely unexpected new role as transducers of extracellular signals.
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