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Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
Published on: May 24, 2016
Meningioma metastatic to the lung
1Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic Rochester, Minn 55905, USA.
Abstract:
Meningiomas constitute 15% to 18% of all primary intracranial and intraspinal tumors. Distant extracranial metastases are reported to occur in fewer than 1 in 1000 cases. Of 1992 primary intracranial meningiomas seen at Mayo Clinic Rochester from 1972 through 1994, we identified 3 (0.15%) with documented extracranial metastasis. A review of the literature suggests that previous craniotomy, venous sinus invasion, local recurrences, histological malignancy, and papillary morphology may be risk factors for systemic spread, as demonstrated in our cases. Although rare, metastatic meningioma should be considered in the differential diagnosis of abnormal findings on chest radiography in patients with known or suspected intracranial meningioma.
Insights
Metastatic meningioma is rare, occurring in less than 0.15% of intracranial cases. Risk factors include prior surgery and tumor characteristics, necessitating consideration in differential diagnoses.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Meningiomas are primary tumors of the central nervous system, accounting for 15-18% of all intracranial and intraspinal neoplasms.
- Extracranial metastases from meningiomas are exceptionally rare, with reported incidences below 0.1%.
Observation:
- A retrospective review identified 3 cases (0.15%) of extracranial meningioma metastasis among 1992 primary intracranial meningiomas at Mayo Clinic (1972-1994).
- Identified risk factors for systemic spread included prior craniotomy, venous sinus invasion, local recurrence, histological malignancy, and papillary morphology.
Findings:
- The study confirms the rarity of extracranial meningioma metastasis.
- Specific pathological and clinical factors are associated with an increased risk of distant spread.
Implications:
- Metastatic meningioma should be included in the differential diagnosis for patients with intracranial meningioma presenting with abnormal chest radiography findings.
- Understanding risk factors may aid in early detection and management of rare metastatic cases.
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