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Convenient synthesis of L-proline benzyl ester
A Córdova1, N N Reed, J A Ashley
1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bioorganic & Medicinal Chemistry Letters
|November 24, 1999
Abstract:
Mesylates or tosylates of delta-hydroxy-L-norvaline esters spontaneously afford L-proline esters upon exposure to aqueous buffer in near quantitative yield. This novel reaction has led to the development of a simple route to optically active proline esters.