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Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues
S De Jonghe1, I Van Overmeire, J Gunst
1University of Gent, Faculty of Pharmaceutical Sciences, Laboratory for Medicinal Chemistry, Belgium.
Bioorganic & Medicinal Chemistry Letters
|November 24, 1999
Abstract:
Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.