Developmental effects of intermittent prenatal exposure to 1,1,1-trichloroethane in the rat

The effects of daily three 1-h exposures to 7000 ppm 1,1,1-trichloroethane (TCE) on physical and behavioral development were examined in Sprague-Dawley rats exposed during the last week of gestation. A sham group was exposed to filtered air. Offspring of both groups were fostered to untreated dams. No significant group differences were detected in total maternal weight gain or food and water consumption, but differences were observed in initial litter characteristics, including a longer gestation period in the TCE group, a smaller number of litters delivered in the TCE group, and fewer live pups per litter in the TCE group. At birth, the total litter weight was less in the TCE group, but there was no significant difference in average pup weight. Pups prenatally exposed to TCE did not differ from shams in day of eye opening, pinnae detachment, or incisor eruption. The TCE group weighed less the first 2 weeks of life, was impaired in its ability to perform the inverted screen, negative geotaxis, and vertical screen tests, and had less forelimb grip strength. Locomotor activity was reduced in the TCE group, and the ratio of brain to body weight was reduced in TCE-exposed offspring. These data provide evidence for neurobehavioral teratogenicity of intermittent prenatal exposure to high concentrations of TCE in rats.